Ionophore nigericin

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August undefined, 2024

WebNigericin sodium salt is a potassium ionophore, exchanges K + for H + across biological membranes, in a similar manner to Valinomycin (Cat. No. 3373). Stimulates mitochondral … WebNigericin is a carboxylic ionophore that exchanges K + (and to a lesser extent Na +) for H + across cell membranes. If one is successful in choosing [K +] o to match [K +] i, then …

Nigericin Data sheet InvivoGen

Web开馆时间：周一至周日7:00-22:30 周五 7:00-12:00; 我的图书馆 Web12 okt. 2015 · Nigericin, a K +,H +-ionophore 1-21 with antibiotic 10, 22-26, antimalarial 27, anti-Toxoplasma gondii 28 and antiviral 11, 29, 30 potency, has been considered for … chubby\u0027s fried chicken

Nigericin sodium salt Supplier CAS 28643-80-3 Tocris Bioscience

Web6 okt. 2016 · Ionophores such as valinomycin and nigericin are potent tools for studying the impact of ion perturbance on cellular functions. To obtain a broader picture about molecular components involved in mediating the effects of these drugs on yeast cells under respiratory growth conditions, we performed a screening of the haploid deletion mutant … Web1 feb. 1978 · Nigericin, an ionophore that exchanges K+ for H+ across most biologic membranes, reversibly inhibited the proliferative response of human lymphocytes … Web1 dec. 2024 · Other compounds, nigericin, indanomycin, monensin, and lasalocid, showed selectivity of about 50–100 fold. ... Ionophore X-206 found to inhibit viral replication in cell cultures. chubby\u0027s fried clams

Nigericin is a potent inhibitor of the early stage of vaccinia virus ...

WebThe ionophore nigericin equilibrates pH across cells so that the final ion gradients depend on the experimental conditions . Fluorescence intensity was measured in triplicate using the Varioskan LUX Multimode Microplate Reader (Thermo Fisher Scientific) for light emitted at 440 nm and 540 nm with reference excitation wavelengths of 329 nm and 384 nm, … WebThe term ionophore (from Greek ion carrier or ion bearer) was proposed by Berton Pressman in 1967 when he and his colleagues were investigating the antibiotic mechanisms of valinomycin and nigericin. [4] Many ionophores are produced naturally by a variety of microbes, fungi and plants, and act as a defense against competing or pathogenic species. chubby\u0027s ft pierceWebIn summary care must be taken when using the putative K+/H+ ionophore nigericin as an experimental tool in synaptosomes, as under standard conditions (i.e. in the presence of … designer grateful dead cashmere sweater

"Web15 apr. 2016 · The role of carboxylic ionophores (including nigericin and monensin) in lysosomal protein degradation was shown previously, and interestingly monensin inhibited autophagy (29). Thus, monensin and nigericin produced opposite effects on pH and on autophagy and mitophagy that again, suggests the effect of intracellular pH on … " - Ionophore nigericin

Ionophore nigericin

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WebNigericin effectively causes intracellular parasites to exit their host cell within 30 min of treatment with the drug. Our results show that nigericin-induced egress depends on … WebNigericin (NSC 292567) sodium salt is an antibiotic derived from Streptomyces hygroscopicus that works by acting as an H+, K+, and Pb2+ ionophore .Nigericin can activate NLRP3 inflammasome to induce pro-inflammatory and immunostimulatory processes. CAS No. 28643-80-3 Selleck's Nigericin (NSC 292567) sodium salt has …

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WebAbstract Ionophore antibiotics are compounds produced by microorganisms (mainly spore-forming bacteria) ; they act by specifically increasing the ion permeability of the cell membrane. In Vol. WebNigericin sodium salt acts as a potassium ionophore. It probably activates NLRP3 through the intracellular potassium (K+) efflux across the membrane [1]. Whether the formation of non‑selective pannexin-1 pores also contributes to NLRP3 activation upon … Inflammasome activation with Nano-SiO 2. NLRP3 Inflammasome Inducer - Silicon … Inflammasome activation with Hemozoin crystals. NLRP3 Inflammasome Inducer … Inflammasome activation with Alum. NLRP3 Inflammasome Inducer - Alum … Needle is a component of the type III secretion systems (T3SS) of intracellular … Rod is a component of the type III secretion systems (T3SS) of intracellular bacteria … Purified Flagellin from Pseudomonas aeruginosa.FLA-PA, a ~52 kDa protein, … Inflammasome activation with CPPD crystals. NLRP3 Inflammasome Inducer … Mincle Agonist - Synthetic analog of the cord factor. Trehalose-6,6-dibehenate …

WebVaccinia virus is the prototypic member of the Orthopoxvirus genus, which also includes variola and monkeypox virus. In this study, we demonstrate that the carboxylic ionophore nigericin is a potent inhibitor of vaccinia virus replication in several human cell lines. In HeLa cells, we found that the 50% inhibitory concentration of nigericin ... WebThe ionophore nigericin transports Pb2+ with high activity and selectivity: a comparison to monensin and ionomycin. Biochemistry, 2004, 43(50): 15956-15965. [3]. Eytan GD, Carlenor E, Rydström J. Energy-linked transhydrogenase. Effects of valinomycin and nigericin on the ATP-driven transhydrogenase reaction catalyzed by reconstituted ...

Web1 dec. 2013 · The release of IL-1beta in response to nigericin, a potassium ionophore, and maitotoxin, a potent marine toxin, was also found to be dependent on cryopyrin. In contrast to Asc-/- macrophages, cells deficient in the gene encoding cryopyrin (Cias1-/-) activated caspase-1 and secreted normal levels of IL-1beta and IL-18 when infected with Gram … WebThe Ca 2+ ionophore A23187 has been used extensively to permit entry of Ca 2+ into cells, which normally have a low native permeability to Ca 2+, ... Nigericin exchanges K + for protons and has been used in many studies of mitochondrial bioenergetics to alter electrical and chemical gradients for protons.

WebProduct name Nigericin Na+ salt, K+ ionophore Description K + ionophore Biological description K + ionophore; exchanges K + for H + across most biological membranes. …

Web25 sep. 2024 · Human African trypanosomiasis (HAT) is caused by Trypanosoma brucei parasites. The T. brucei aquaglyceroporin isoform 2, TbAQP2, has been linked to the uptake of pentamidine. Negative membrane potentials and transmembrane pH gradients were suggested to promote transport of the dicationic antitrypanosomal drug. Application of … designer graphic white hills teeWebIonophore Molecular Formula C40H68O11 Physical Form Solid Product Type Nigericin Figures Dual-emission ratiometric measurement of lysosomal pH using LysoSensor™ … designer graphic t shirtWebNigericin acts as an H +, K +, Pb 2+ ionophore. Most commonly it is an antiporter of H + and K +. In the past nigericin was used as an antibiotic active against gram positive bacteria. … designer greek clothingWebNigericin is a carboxylic ionophore that exchanges K + (and to a lesser extent Na +) for H + across cell membranes. If one is successful in choosing [K +] o to match [K +] i, then pH i should equal pH o. Thus, by altering pH o, one can measure the dye's spectral properties over a range of pH i values. chubby\u0027s fultonWebLike nigericin, the ionophores A204 and lasalocid induced the release and maturation of IL-1 beta. The electrogenic potassium ionophore valinomycin, however, did not stimulate these post-translational events. Addition of nigericin or lasalocid to LPS-stimulated cells produced a rapid intracellular acidification; ... chubby\u0027s fried chicken new orleans laWebNigericin, an ionophore that exchanges K+ for H+ across most biologic membranes, reversibly inhibited the proliferative response of human lymphocytes to phytohemagglutinin (PHA). Inhibition occurred at nigericin concentrations of 10 (-8) M or greater, and only during the early event of mitogenesis. chubby\\u0027s fultonWeb2 dagen geleden · 3.3 IL-6 cytokine secretion in BMDM of diabetic animals stimulated with LPS and Nigericin. We have also investigated the effect of hyperglycemia concomitant with LPS+Nigericin stimulation to assess the secretion of the pro-inflammatory cytokine IL-6 ().After 2, 4, 6 and 24 hours of incubation, BMDM from diabetic and non-diabetic animals … chubby\u0027s garage