Ctcf is a barrier for 2c-like reprogramming
Webfactor (CTCF) is a barrier for 2C-like reprogramming. Indeed, forced conversion to a 2C-like state by the transcription factor DUX is associated with DNA damage at a subset of … WebHere, we show that the CCCTC-binding factor (CTCF) is a barrier for 2C-like reprogramming. Indeed, forced conversion to a 2C-like state by the transcription factor DUX is associated with DNA damage at a subset of CTCF binding sites. Depletion of CTCF in ESC efficiently promotes spontaneous and asynchronous conversion to a 2C-like …
Ctcf is a barrier for 2c-like reprogramming
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WebOct 18, 2024 · CTCF controls the metabolic switch occurring at the morula-to-blastocyst transition Summary The eukaryotic genome is organized in 3D at different scales. This structure is driven and maintained by different chromatin states and by architectural factors, such as the zinc finger protein CTCF. WebMar 3, 2024 · In both Calu-3 (Fig. 1A) and 16HBE14o- (Suppl. Fig. S-IIIA) cells, the most significant motifs were those for CCCTC-Binding Factor (CTCF) (Bell, West and Felsenfeld, 1999) and BORIS/CCCTC-Binding Factor Like (CTCFL)(Loukinov, Pugacheva, Vatolin et al., 2002). Also enriched at sites of BRD8 occupancy in both Calu-3 and 16HBE14o- …
WebMar 19, 2024 · CTCF is a barrier for 2C-like reprogramming. Interplay between CTCF boundaries and a super enhancer controls cohesin extrusion trajectories and gene … WebMay 27, 2024 · Although not strictly totipotent, 2CLCs are considered totipotent-like cells and are therefore a powerful cellular model to study molecular features related to totipotency. 2CLCs emerge most...
WebAug 3, 2015 · In the comparison of p60KD-induced 2C–like cells: with zygote p=1; with 2-cell p=2.092e-13; with 4-cell p=0.051; with 8-cell p=1; with 16-cell p=1; with early blastocyst p=1. In the comparison of...
WebMay 20, 2024 · A novel model to study the transition has been recently established, named the 2-cell-like (2C-like) model. The 2C-like cells are rare totipotent-like cells in the mouse embryonic stem cell (mESC) culture. Pluripotent mESCs can spontaneously transit into and out of the 2C-like state.
WebAug 22, 2024 · Olbrich T, Vega-Sendino M, Tillo D, Wu W, Zolnerowich N, Pavani R, Tran AD, Domingo CN, Franco M, Markiewicz-Potoczny M et al (2024) CTCF is a barrier for 2C-like reprogramming. Nature Communications 12: 4856 Crossref CAS PubMed Web of Science® Google Scholar bir ghost corporationWebSep 7, 2024 · CTCF is a Barrier for Totipotent-like Reprogramming. Organism. Mus musculus. Experiment type. Genome binding/occupancy profiling by high throughput sequencing. Other. Summary. This SuperSeries is composed of the SubSeries listed below. birght126WebMar 7, 2024 · Perturbations that slow replication fork speed promote 2-cell-like cell emergence and improve somatic cell nuclear transfer reprogramming and formation of … dancing clothes sims 3WebAug 11, 2024 · [Nature Communications] Researchers showed that the CCCTC-binding factor (CTCF) was a barrier for 2C-like reprogramming. Depletion of CTCF in ESCs … birge wallpaper companyWebCTCF is a barrier for 2C-like reprogramming Nature Communications August 11, 2024 See publication Following Trypanosoma cruzi RPA … birgham scotlandWebFeb 17, 2016 · The observed latency and low efficiency of induced pluripotent stem cell generation during direct reprogramming reflect epigenetic barriers that are imposed during differentiation. Once these... birght116WebA similar activation occurs in mouse embryonic stem cells, giving rise to 2-cell-like cells (2CLCs). Though the molecular mechanism underlying this expanded 2CLC potency caused by Dux activation has been partially revealed, the regulation mechanisms controlling Dux expression remain elusive. dancing clock demonz lyrics