Cisplatin coordination complex
WebThe platinum coordination complex cisplatin, or cis -diamminedichloroplatinum (II) (see Figure 1 ), functions as a cytotoxic anticancer chemotherapy agent and shows a remarkable degree of selectivity in destroying testicular cancer cells. WebAug 15, 2024 · In simple terms, the coordination number of a complex is influenced by the relative sizes of the metal ion and the ligands and by electronic factors, such as charge which is dependent on the electronic configuration of the metal ion. Introduction
Cisplatin coordination complex
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WebSep 5, 2015 · Taken together, the complex has been shown to be a potential DNA damaging agent and, in the light of the superiority of the complex over cisplatin, we are further investigating the possibility of targeted nano-delivery of … WebConsidering the strong coordination capacity of copper, a variety of organic ligands, especially carboxyl-modified organic ligands, can be used to synthesize Cu-MOF through coordination reaction with copper. ... Copper complexes as anticancer agents. Cisplatin is a milestone in the field of metal complexes for cancer treatment, but because of ...
WebMar 29, 2024 · Reviewed on 3/29/2024. Cisplatin: An anticancer drug that belongs to the family of drugs called platinum compounds. Cisplatin is used in the treatment of a wide … WebNov 13, 2014 · The anticancer activity of this complex was screened against a panel of cancer cell lines. Remarkably, it exhibited IC50 values that were an order of magnitude lower than those of cisplatin. This complex also displayed potencies superior to those of cisplatin against 3D tumor spheroids.
WebSep 18, 2024 · National Center for Biotechnology Information WebCisplatin was the first platinum complex to be used clinically but is being replaced by carboplatin. Cisplatin can cause typical type A ADRs such as marrow depression and …
WebThe additional coordination positions offer the ability to design combinatorial therapies in a single complex, which is potentially more effective than the precursor platinum(II) complex. Specifically, platinum(IV) complexes are proposed to be stable in the bloodstream due to their low spin d 6 electronic configuration [ 32 ].
WebCancer continues to be responsible for the deaths of more than 9 million people worldwide each year. Current treatment options are diverse, but low success rates, particularly for those with late-stage cancers, continue to be a problem for clinicians and their patients. The effort by researchers globally to find alternative treatment options is ongoing. In the … porsche rated tiresWebMontgomery County, Kansas. Date Established: February 26, 1867. Date Organized: Location: County Seat: Independence. Origin of Name: In honor of Gen. Richard Montgomery (1738-1775), a Revolutionary War hero who led the army into Canada, capturing the city of Montreal; he died while attempting to capture Quebec. porsche rated tyresCisplatin is a chemotherapy medication used to treat a number of cancers. These include testicular cancer, ovarian cancer, cervical cancer, bladder cancer, head and neck cancer, esophageal cancer, lung cancer, mesothelioma, brain tumors and neuroblastoma. It is given by injection into a vein. Common side … See more Cisplatin is administered intravenously as short-term infusion in normal saline for treatment of solid and haematological malignancies. It is used to treat various types of cancers, including sarcomas, some See more Cisplatin is the square planar coordination complex cis-[Pt(NH3)2Cl2]. The prefix cis indicates the cis isomer in which two similar ligands are in adjacent positions. The systematic … See more Syntheses of cisplatin start from potassium tetrachloroplatinate. Several procedures are available. One obstacle is the facile formation of Magnus's green salt (MGS), which has the same empirical formula as cisplatin. The traditional way to avoid MGS involves the … See more Cisplatin has a number of side effects that can limit its use: • Nephrotoxicity (kidney damage) is the primary dose-limiting side effect and is of major clinical … See more Cisplatin interferes with DNA replication, which kills the fastest proliferating cells, which in theory are cancerous. Following administration, one chloride ion is slowly displaced by water … See more The compound cis-[Pt(NH3)2Cl2] was first described by Italian chemist Michele Peyrone in 1845, and known for a long time as Peyrone's … See more Cisplatin has been studied with Auger therapy to increase the therapeutic effects of cisplatin, without increasing normal tissue toxicities. See more porsche ratingsWebThe original: Cisplatin. Cisplatin is an example of a metal complex. The name itself is a merger of information referring to the stereoisomeric geometry adopted, cis-, and the platinum metal at the heart of the complex, -platin. Its formula is cis -PtCl 2 (NH 3) 2, with the platinum metal centre bonded to four ligands: two ammonia (NH 3) and ... porsche rcWebJul 4, 2024 · Coordination numbers of two and three are common for d 10 metal ions. Tetrahedral and square planar complexes have a coordination number of four; trigonal … irish corned beef tacosWebcis-Diamminedichloroplatinum(II): effects of a representative metal coordination complex on mammalian cells cis-Diamminedichloroplatinum(II): effects of a representative metal … porsche ready readersWebMay 10, 2024 · Notable examples include the anticancer drugs cisplatin ( PtCl 2 ( NH 3) 2 ). A square planar complex also has a coordination number of 4. The structure of the complex differs from tetrahedral because the ligands form a simple square on the x and y axes. Because of this, the crystal field splitting is also different (Figure 1 ). porsche rate